Regulation of Metastasis and DNA Damage Resistance Pathways by Transposable Elements
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منابع مشابه
Proposed mechanism for the initiation of transposable element silencing by the RDR6-directed DNA methylation pathway
The activity of transposable elements is epigenetically suppressed by both transcriptional and post-transcriptional mechanisms. We recently identified a direct connection between the small RNA-mediated post-transcriptional mRNA degradation of actively transcribing transposable elements and the de novo methylation of transposable element DNA, providing a mechanistic link between these two establ...
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Prokaryote, viruses, and eukaryotes chromosomes contain fragments of DNA can move and migrate to other parts of the chromosome calling as Transposition and play an important role in new combinations of gene production. DNA fragments carrier the genes or transposons are the transposable elements that may called gene mutant also. Transposons can move to another position of the same chromosome or ...
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Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencin...
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DNA demethylation in Arabidopsis (Arabidopsis thaliana) is mediated by DNA glycosylases of the DEMETER family. Three DEMETER-LIKE (DML) proteins, REPRESSOR OF SILENCING1 (ROS1), DML2, and DML3, function to protect genes from potentially deleterious methylation. In Arabidopsis, much of the DNA methylation is directed by RNA interference (RNAi) pathways and used to defend the genome from transpos...
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Background: Chromosome abnormalities are associated with poor morphology and development in human preimplantation embryos, all together lead to poor outcomes. This study aimed to explore altered expression of DNA damage pathways in “poor morphological and development embryos with sever aneuploidies”. Materials and Methods: Surplus day-4 embryos of PGD cases were pooled in two groups: Poor progn...
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